Negative selection pressure against premature protein truncation is reduced by alternative splicing and diploidy
نویسندگان
چکیده
منابع مشابه
Negative selection pressure against premature protein truncation is reduced by alternative splicing and diploidy.
The importance of alternative splicing in many genomes has raised interesting questions about its role in evolution. We analyzed 13 384 full-length transcript isoforms from human and 2227 isoforms from mouse to identify sequences containing premature termination codons (PTCs) that are likely targets of mRNA nonsense-mediated decay. We found that alternatively spliced isoforms have a much higher...
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ژورنال
عنوان ژورنال: Trends in Genetics
سال: 2004
ISSN: 0168-9525
DOI: 10.1016/j.tig.2004.07.009